Histoplasmosis is an infection caused by breathing in spores of a fungus often found in bird and bat droppings. Histoplasmosis is most commonly transmitted when these spores become airborne, often during cleanup or demolition projects.

Soil contaminated by bird or bat droppings also can transmit histoplasmosis, so farmers and landscapers are at a higher risk of contracting the disease. In the United States, histoplasmosis commonly occurs in the Mississippi and Ohio river valleys, though it can occur in other areas, too.

Most people with histoplasmosis never develop symptoms and aren't aware they're infected. But for some people — primarily infants and those with compromised immune systems — histoplasmosis can be serious. Effective treatments are available for even the most severe forms of histoplasmosis.

Symptoms Causes Risk factors Complications Prevention

Several types of histoplasmosis exist. The mildest form produces no signs or symptoms, but severe infections can be life-threatening. When signs and symptoms do occur, they usually appear three to 17 days after exposure and may include:

  • Fever
  • Chills
  • Headache
  • Muscle aches
  • Dry cough
  • Chest discomfort

In some people, histoplasmosis can also produce joint pain and a rash. People who have an underlying lung disease, such as emphysema, may develop a chronic form of histoplasmosis.

Symptoms of chronic histoplasmosis may include weight loss and a cough that brings up blood. The symptoms of chronic histoplasmosis sometimes can mimic those of tuberculosis.

Severe histoplasmosis

The most severe variety of histoplasmosis occurs primarily in infants and in people with compromised immune systems. Called disseminated histoplasmosis, this variety can affect nearly any part of your body, including your mouth, liver, central nervous system, skin and adrenal glands. If untreated, disseminated histoplasmosis is usually fatal.

When to see a doctor

Contact your doctor if you develop flu-like symptoms after being exposed to bird or bat droppings — especially if you have a weakened immune system.

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