IMPORTANT NOTICE: At Fortis Healthcare, we are fully supportive of the National priorities set out by the Hon’ble Prime Minister of India. Further to the directives of the Government provided in their press release dated 8th Nov 2016, payments at Government hospitals can be made through 500 and 1000 Rupee denomination notes. In view of the hardship being caused to the large number of patients at private hospitals, we have made an urgent representation to the Government that this exemption should apply equally, for payments, at private hospitals. We are following up with the authorities and hope the Government will step in quickly to resolve this anomaly. Meanwhile, at Fortis hospitals across the country, we continue to accept payments through credit card, debit card and electronic banking transfers. As 500 and 1000 Rupee denomination notes are no longer legal tender we are only accepting 100 Rs and lower currency notes. As per Government regulation, a PAN card and legitimate ID proof is however required for payments in cash exceeding Rs 50,000. Meanwhile we continue to ensure that emergency cases get immediate medical attention without delay whatsoever and have put in more administrative staff and help desks to assist patients.

Krabbe disease

Krabbe (KRAH-buh) disease is an inherited disorder that destroys the protective coating (myelin) of nerve cells in the brain and throughout the nervous system.

In most cases, signs and symptoms of Krabbe disease develop in babies before 6 months of age, and the disease usually results in death by age 2. When it develops in older children and adults, the course of the disease can vary greatly.

There's no cure for Krabbe disease, and treatment focuses on supportive care. However, stem cell transplants have shown some success in infants who are treated before the onset of symptoms and in some older children and adults.

Krabbe disease affects about 1 in 100,000 people in the United States. It is also known as globoid cell leukodystrophy.


Symptoms Causes Risk factors Complications

In most cases, the signs and symptoms of Krabbe disease appear during the first few months of life. They begin gradually and progressively worsen.

Infants

Common signs and symptoms early in the course of the disease include the following:

  • Feeding difficulties
  • Unexplained crying
  • Extreme irritability
  • Fever with no sign of infection
  • Declines in alertness
  • Delays in typical developmental milestones
  • Muscle spasms
  • Loss of head control
  • Frequent vomiting

As the disease progresses, signs and symptoms become more severe. They may include:

  • Seizures
  • Loss of developmental abilities
  • Progressive loss of hearing and sight
  • Rigid, constricted muscles
  • Stiff, fixed posture
  • Progressive loss of ability to swallow and breathe

Older children and adults

When Krabbe disease develops later in childhood or during adulthood, signs and symptoms can vary widely. They may include:

  • Progressive loss of vision
  • Difficulty walking (ataxia)
  • Decline in thinking skills
  • Loss of manual dexterity
  • Muscles weakness

As a general rule, the younger the age that Krabbe disease occurs, the faster the disease progresses and the more likely it is to result in death.

Some people diagnosed during adolescence or adulthood may have less severe symptoms, with muscle weakness as a primary condition. They may have no impairment of their thinking skills.

When to see a doctor

The early signs and symptoms of Krabbe disease in infancy can indicate any number of diseases or developmental problems. Therefore, it's important to get a prompt and accurate diagnosis if your child is experiencing any signs or symptoms of the disease.

Signs and symptoms most often associated with older children and adults also are not specific to Krabbe disease and require a timely diagnosis.


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