Cardiomyopathy is a disease of abnormal heart muscle. There are three main types of cardiomyopathy — dilated, hypertrophic and restrictive. Cardiomyopathy makes it harder for your heart to pump and deliver blood to the rest of your body. Cardiomyopathy can lead to heart failure.
Cardiomyopathy can be treated. The type of treatment you'll receive depends on which type of cardiomyopathy you have and how serious it is. Your treatment may include medications, surgically implanted devices or, in severe cases, a heart transplant.
In the early stages, people with cardiomyopathy may not have any signs and symptoms. But as the condition advances, signs and symptoms usually appear. Cardiomyopathy signs and symptoms may include:
Breathlessness with exertion or even at rest
Swelling of the legs, ankles and feet
Bloating of the abdomen due to fluid buildup
Irregular heartbeats that feel rapid, pounding or fluttering
Dizziness, lightheadedness and fainting
No matter what type of cardiomyopathy you have, signs and symptoms tend to get worse unless treated. In certain people, this worsening happens quickly, while in others, cardiomyopathy may not worsen for a long time.
When to see a doctor
See your doctor if you have one or more of the signs and symptoms associated with cardiomyopathy. Call emergency number if you experience severe difficulty breathing, fainting or chest pain that lasts for more than a few minutes.
Because the condition is sometimes hereditary, your doctor may advise that your family members be examined for cardiomyopathy.
Often, the cause of the cardiomyopathy is unknown. In some people, however, doctors are able to identify some contributing factors. Possible causes of cardiomyopathy include:
Long-term high blood pressure
Heart valve problems
Heart tissue damage from a previous heart attack
Chronic rapid heart rate
Metabolic disorders, such as obesity, thyroid disease or diabetes
Nutritional deficiencies of essential vitamins or minerals, such as thiamin (vitamin B-1)
Drinking too much alcohol over many years
Use of cocaine, amphetamines or anabolic steroids
Use of some chemotherapy drugs to treat cancer
Certain viral infections, which may injure the heart and trigger cardiomyopathy
Iron buildup in your heart muscle (hemochromatosis)
The three types of cardiomyopathy are:
Dilated cardiomyopathy. This is the most common type of cardiomyopathy. In this disorder, the pumping ability of your heart's main pumping chamber — the left ventricle — becomes less forceful. The left ventricle becomes enlarged (dilated) and can't effectively pump blood out of the heart. Although this type can affect people of all ages, it occurs most often in middle-aged people and is more likely to affect men. Some people with dilated cardiomyopathy have a family history of the condition. In others, dilated cardiomyopathy may occur as a result of infection, chemotherapy or alcohol use. The cause may also be unknown (idiopathic).
Hypertrophic cardiomyopathy. This type involves abnormal growth or thickening of your heart muscle, particularly affecting the muscle of your heart's main pumping chamber. As thickening occurs, the heart tends to stiffen and the size of the pumping chamber may shrink, interfering with your heart's ability to deliver blood to your body. Hypertrophic cardiomyopathy can develop at any age, but the condition tends to be more severe if it becomes apparent during childhood. Most affected people have a family history of the disease, and some genetic mutations have been linked to hypertrophic cardiomyopathy.
Restrictive cardiomyopathy. The heart muscle in people with restrictive cardiomyopathy becomes rigid and less elastic, meaning the heart can't properly expand and fill with blood between heartbeats. While restrictive cardiomyopathy can occur at any age, it most often tends to affect older people. It's the least common type of cardiomyopathy and can occur for no known reason (idiopathic). The condition may also be caused by diseases elsewhere in the body that affect the heart, such as a disorder that causes the buildup of abnormal proteins (amyloidosis) or a disorder that causes abnormal blood cells to damage the heart (eosinophilic heart disease).
There are a number of risk factors that can increase your risk of cardiomyopathy, including:
Family history. People with a family history of cardiomyopathy, heart failure and sudden cardiac arrest are more likely to develop cardiomyopathy than are those without a family history of heart problems.
Obesity. Excess weight makes the heart work harder, which increases the risk of cardiomyopathy and heart failure.
Alcoholism. People who abuse alcohol can damage their hearts, and cardiomyopathy can be a consequence. The risk increases significantly after more than five years of drinking seven to eight drinks daily.
Illicit drug use. Drugs, such as cocaine, amphetamines and anabolic steroids, may increase the risk of cardiomyopathy.
Cancer treatments. While necessary to treat cancer, many cancer treatments can damage some healthy cells too. Certain chemotherapy drugs and radiation therapy can increase the risk of cardiomyopathy.
Diabetes. Having diabetes ups the risk of cardiomyopathy, heart failure and other heart problems.
Thyroid disorders. Having an under- or overactive thyroid gland can increase your risk of cardiomyopathy.
Hemochromatosis. This disorder causes the body to store excess iron, and it has been linked to an increased risk of dilated cardiomyopathy.
Having cardiomyopathy may lead to other heart conditions, including:
Heart failure. Heart failure means your heart can't pump enough blood to meet your body's needs. The thickened, stiffened or weakened heart muscle due to cardiomyopathy can become unable to pump or can stop blood from flowing out of the heart. Left untreated, heart failure can be life-threatening.
Blood clots. Because your heart can't pump effectively, you're more likely to have blood clots form in your heart if you have cardiomyopathy. If clots are pumped out of the heart and enter your bloodstream, they can block the blood flow to other organs, including your heart and brain. If clots develop on the right side of your heart, they may travel to your lungs (pulmonary embolism). To reduce your risk, your doctor may prescribe a blood thinner (anticoagulant medication), such as aspirin, clopidogrel (Plavix), apixaban, dabigatran, rivaroxaban or warfarin (Coumadin, Jantoven).
Valve problems. Because people with dilated cardiomyopathy have an enlarged heart, the mitral and tricuspid valves — two of the heart's four valves — may not close properly, leading to a backward flow of blood. This flow creates sounds called heart murmurs.
Cardiac arrest and sudden death. All forms of cardiomyopathy can lead to abnormal heart rhythms. Some of these heart rhythms are too slow to keep blood flowing through your heart effectively, and some are too fast to allow the heart to beat properly. In either case, these abnormal heart rhythms can result in fainting or, in some cases, sudden death if your heart stops beating effectively.
In many cases, you can't prevent cardiomyopathy. Let your doctor know if you have a family history of the condition.
You can help reduce your chance of heart failure by avoiding some of the conditions that can contribute to a weak heart, including the abuse of alcohol or cocaine or not getting enough vitamins and minerals. Controlling high blood pressure with diet and exercise also prevents many people from developing heart failure later in life.
If you think you may have cardiomyopathy or are worried about your risk because of a family history, make an appointment with your primary care doctor. He or she may refer you to a heart specialist (cardiologist).
Because appointments can be brief, and because there's often a lot of ground to cover, it's a good idea to be prepared for your appointment. Here's some information to help you get ready for your appointment and what to expect from your doctor.
What you can do
Be aware of any pre-appointment restrictions. At the time, you make the appointment, be sure to ask if there's anything you need to do in advance, such as restrict your diet.
Write down any symptoms you're experiencing, including any that may seem unrelated to cardiomyopathy.
Write down key personal information, including a family history of cardiomyopathy, heart disease, stroke, high blood pressure or diabetes and any major stresses or recent life changes.
Make a list of all medications, as well as any vitamins or supplements, that you're taking.
Take a family member or friend along, if possible. Sometimes it can be difficult to remember all of the information provided to you during an appointment. Someone who accompanies you may remember something that you missed or forgot.
Be prepared to discuss your diet and exercise habits. If you don't already follow a diet or exercise routine, be ready to talk to your doctor about any challenges you might face in getting started.
Write down questions to ask your doctor.
Your time with your doctor is limited, so preparing a list of questions will help you make the most of your time together. List your questions from most important to least important in case time runs out. For cardiomyopathy, some basic questions to ask your doctor include:
What's the most likely cause of my symptoms?
What are other possible causes?
What kinds of tests do I need? Do these tests require any special preparation?
What treatment options are available, and which do you recommend for me?
What foods should I eat or avoid?
Is it OK for me to exercise? What level of activity is OK?
How often should I be screened?
Should I tell my family members to be screened for cardiomyopathy?
I have other health conditions. How can I best manage these conditions together?
Is there a generic alternative to the medicine you're prescribing me?
Are there any brochures or other printed material that I can take home with me? What websites do you recommend visiting?
In addition to the questions that you've prepared to ask your doctor, don't hesitate to ask additional questions that occur to you during your appointment.
What to expect from your doctor
Your doctor is likely to ask you a number of questions. Being ready to answer them may reserve time to go over any points you want to spend more time on. Your doctor may ask:
When did you first begin experiencing symptoms?
Do you have symptoms all the time, or do they come and go?
How severe are your symptoms?
What, if anything, seems to improve your symptoms?
What, if anything, appears to worsen your symptoms?
Do any of your blood relatives have cardiomyopathy or other types of heart disease?
Your doctor will conduct a physical examination, take a personal and family medical history, and ask when your symptoms occur — for example, whether exercise brings on your symptoms. If your doctor thinks you have cardiomyopathy, you may need to undergo several tests to confirm the diagnosis. These tests may include:
Chest X-ray. An image of your heart will show whether it's enlarged.
Echocardiogram. An echocardiogram uses sound waves to produce images of the heart. Your doctor can use these images to examine the size and function of your heart and its motions as it beats. This test checks your heart valves and helps your doctor determine the cause of your symptoms.
Electrocardiogram (ECG). In this noninvasive test, electrode patches are attached to your skin to measure electrical impulses from your heart. An ECG can show disturbances in the electrical activity of your heart, which can detect abnormal heart rhythms and areas of injury.
Cardiac catheterization and biopsy. In this procedure, a thin tube (catheter) is inserted in your groin and threaded through your blood vessels to your heart, where a small sample (biopsy) of your heart can be extracted for analysis in the laboratory. Pressure within the chambers of your heart can be measured to see how forcefully blood pumps through your heart. Pictures of the arteries of the heart can be taken during the procedure (coronary angiogram) to ensure that you do not have any blockage.
Cardiac magnetic resonance imaging (MRI). Cardiac MRI is an imaging technique that uses magnetic fields and radio waves to create images of your heart. Cardiac MRI may be used in addition to echocardiography, particularly if the images from your echocardiogram aren't helpful in making a diagnosis.
Blood tests. One blood test can measure B-type natriuretic peptide (BNP), a protein produced in your heart. Your blood level of BNP rises when your heart is subjected to the stress of heart failure, a common complication of cardiomyopathy.
A variety of other blood tests may be done, including those to check your kidney function and look for anemia and thyroid problems. Your iron level may be measured. Having too much may indicate an iron overload disorder called hemochromatosis. Accumulating too much iron in your heart muscle can weaken it and cause cardiomyopathy.
The overall goals of treatment for cardiomyopathy are to manage your signs and symptoms, prevent your condition from worsening, and reduce your risk of complications. Treatment varies by which major type of cardiomyopathy you have.
If you're diagnosed with dilated cardiomyopathy, your doctor may recommend medications, surgically implanted devices or a combination of both. The medications you may be prescribed include:
Angiotensin-converting enzyme (ACE) inhibitors to improve your heart's pumping capability, such as enalapri, lisinopril, ramipril and captopril.
Angiotensin receptor blockers (ARBs) for those who can't take ACE inhibitors, such as losartan and valsartan.
Beta blockers to improve heart function, such as carvedilol and metoprolol.
Digoxin (Lanoxin). This drug, also referred to as digitalis, tends to slow the heartbeat and help the heart pump more strongly. Digoxin may reduce heart failure symptoms and reduce the need for hospitalization for heart failure.
Diuretics. Often called water pills, diuretics make you urinate more frequently and keep fluid from collecting in your body. Commonly prescribed diuretics for heart failure include bumetanide and (Lasix). The drugs also decrease fluid in your lungs, so you can breathe more easily. One diuretic, spironolactone (Aldactone), may also be helpful in treating scarring of your heart tissue.
Another option for some people with dilated cardiomyopathy is a special pacemaker that coordinates the contractions between the left and right ventricles (biventricular pacing). In people who may be at risk of serious arrhythmias, drug therapy or an implantable cardioverter-defibrillator (ICD) may be options. An ICD is a small device — about the size of a box of matches — implanted in your chest to continuously monitor your heart rhythm and deliver electrical shocks when needed to control abnormal, rapid heartbeats. The device can also work as a pacemaker.
Your doctor may recommend beta blockers to relax your heart, slow its pumping action and stabilize its rhythm. These medications include Lopressor or calcium channel blockers, such as verapamil. Medications are often the preferred treatment for hypertrophic cardiomyopathy.
If medications don't work, you may need surgery or a medical device to treat your condition. Options include:
Septal myectomy. This is an open-heart operation in which the surgeon removes part of the thickened, overgrown heart muscle wall (septum) that separates the two bottom heart chambers (ventricles). Removing part of this overgrown muscle improves blood flow and reduces mitral regurgitation. Myectomy is used if medications don't relieve symptoms.
Septal ablation. Also called septal alcohol ablation, this is a treatment in which a small portion of the thickened heart muscle is destroyed by injecting alcohol through a catheter into the artery supplying blood to it. There are possible complications with this procedure, including heart block — a disruption of the heart's electrical system — which requires implantation of a pacemaker. The long-term success of this procedure isn't yet known, but it's becoming more commonly used.
Implantable cardioverter-defibrillator (ICD). This is a pager-sized device implanted in your chest like a pacemaker. An ICD continuously monitors your heartbeat. If a life-threatening arrhythmia occurs, the ICD delivers precisely calibrated electrical shocks to restore a normal heart rhythm. A small number of people with hypertrophic cardiomyopathy are at risk of sudden cardiac death because of abnormal heart rhythms. In these high-risk individuals, many doctors recommend the implantation of an ICD.
Pacemaker implantation. A pacemaker is a small electronic device inserted under your skin that sends electrical signals to your heart to monitor and regulate your heartbeat. Pacemaker implantation is generally not as effective as surgical options, but it's sometimes used in older people who want to avoid more-invasive procedures.
Treatment for restrictive cardiomyopathy focuses on improving symptoms. Your doctor will recommend you pay careful attention to your salt and water intake and monitor your weight daily. Your doctor may also recommend you take diuretics if sodium and water retention becomes a problem. You may be prescribed medications to lower your blood pressure and control fast or irregular heart rhythms. If the cause of your restrictive cardiomyopathy is found, treatment will also be directed at the underlying disease, such as amyloidosis.
Many of the medications that doctors prescribe for cardiomyopathy may have side effects. Be sure to discuss these possible side effects with your doctor before taking any of these drugs.
Heart transplant and ventricular assist devices (VADs)
If you have severe cardiomyopathy and medications can't control your symptoms, a heart transplant may be an option. Because of the shortage of donor hearts, even people who are critically ill may have a long wait before having a heart transplant. In some cases, a mechanical heart assist device can help critically ill people as they wait for an appropriately matched donor. These devices — known as ventricular assist devices (VADs) or the more commonly used left ventricular assist devices (LVADs), which support the left ventricle — can help blood circulate through your heart for months or even years. A VAD may allow you to live outside the hospital while you wait. In some people who aren't candidates for a heart transplant, VAD therapy could be a long-term treatment option. Devices such as a total artificial heart also are available. The total artificial heart supports both the left and right ventricles for people waiting for heart transplants. New mechanical devices to support the heart continue to be developed and improved.
Coenzyme Q10 is a nutrient found in the body, and in some meats and seafood. Taking coenzyme Q10 supplements may reduce shortness of breath and the collection of excess fluid. However, the supplement hasn't been well studied in cardiomyopathy. Discuss the use of coenzyme Q10 or any supplement you're considering taking with your doctor to ensure that it won't interact with any medications you're currently taking.