Depo-Provera is a well-known brand name for medroxyprogesterone, a contraceptive injection for women that contains the hormone progestin. Depo-Provera is given as an injection once every three months. Depo-Provera typically suppresses ovulation, keeping your ovaries from releasing an egg. Depo-Provera also thickens cervical mucus to keep sperm from reaching the egg.Medroxyprogesterone acetate is also available in a lower dosage. This version is called Depo-SubQ Provera 104. While Depo-Provera is injected deep into the muscle, Depo-SubQ Provera 104 is injected just beneath the skin.Depo-Provera and Depo-SubQ Provera 104 have similar benefits and risks. To use Depo-Provera or Depo-SubQ Provera 104, you'll need to visit your doctor or other health care provider.