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Acanthosis nigricans

Acanthosis nigricans (ak-an-THOE-sis NIE-grih-kuns) is a skin condition characterized by areas of dark, velvety discoloration in body folds and creases. The affected skin can become thickened and may smell bad. Most often, acanthosis nigricans affects your armpits, groin and neck.

These skin changes typically occur in people who are obese or have diabetes. Children who develop the condition are at higher risk of developing type 2 diabetes. More rarely, acanthosis nigricans can be a warning sign of a cancerous tumor in an internal organ, such as the stomach or liver.

Acanthosis nigricans is most common in Native Americans, blacks and Hispanics. There's no specific treatment for acanthosis nigricans. Treatment of underlying conditions may restore some of the normal color and texture to affected areas of skin.

Symptoms Causes Risk factors Complications

Skin changes are the only signs of acanthosis nigricans. You'll notice dark, thickened, velvety skin in body folds and creases — typically in your armpits, groin and neck. The skin changes appear slowly, sometimes over months or years. The affected skin may also smell bad or itch.

When to see a doctor

Consult your doctor if you notice changes in your skin — especially if the changes appear suddenly. You may have an underlying condition that needs treatment.

Acanthosis nigricans has been associated with:

  • Insulin resistance. Most people who have acanthosis nigricans have also become resistant to insulin, a hormone secreted by the pancreas that allows your body to process sugar. Insulin resistance is what eventually causes type 2 diabetes.
  • Obesity. Most people who develop acanthosis nigricans are overweight or obese, which is a strong risk factor for developing insulin resistance.
  • Hormonal disorders. Acanthosis nigricans often occurs in people who have disorders such as ovarian cysts, underactive thyroids or problems with the adrenal glands.
  • Certain drugs. Medications such as oral contraceptives and corticosteroids, such as prednisone, may cause acanthosis nigricans — as can high doses of niacin.
  • Cancer. Acanthosis nigricans also sometimes occurs when a cancerous tumor begins growing in an internal organ, such as the stomach, colon or liver.

Acanthosis nigricans risk factors include:

  • Obesity. The heavier you are, the higher your risk of acanthosis nigricans.
  • Race. Acanthosis nigricans is most common in American Indians, Hispanics and blacks.
  • Genetics. Some types of acanthosis nigricans appear to be hereditary.

People who have acanthosis nigricans are much more likely to develop type 2 diabetes. They also should be thoroughly checked for the types of cancers that have been linked to the disorder.

© 1998-2015 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. Terms of use

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