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Haematology

Genomics in Lymphomas: What’s New and Why It Matters for You

admin May 08, 2025

From the Fortis Institute of Genomic Medicine 

When someone hears the word "lymphoma," it’s natural to feel overwhelmed. But did you know that cutting-edge genomic testing is transforming how we diagnose, treat, and monitor lymphomas—without even needing a biopsy needle in some cases? 

Welcome to the future of cancer care: Genomics + Liquid Biopsy. 

What Is Genomic Testing—and Why Is It a Game Changer in Lymphomas? 

Genomic testing looks into DNA of cancer cells to find specific mutations or changes that drive the disease. Think of it like a "genetic fingerprint" that helps doctors understand exactly what type of lymphoma you have—and how best to treat it. 

Until recently, all this required a painful tissue biopsy. But now, with liquid biopsy, we can gather the same vital information from a simple blood sample. 

Why Should You Get Genomic Testing If You Have Lymphoma? 

  • Precise Diagnosis 
    Lymphomas aren’t just one disease—they include many subtypes like DLBCL, follicular lymphoma, mantle cell lymphoma, and more. Genomics helps us identify exactly which one you have, and if it’s an aggressive or slow-growing form. 

  • Targeted Treatment Options 
    Some mutations respond better to newer, more personalized therapies. For instance, if a gene like EZH2, TP53, or MYD88 is mutated, your treatment plan may change entirely. No more one-size-fits-all. 

  • Avoid Over- or Under-Treatment 
    By understanding your tumor's behavior at the molecular level, we avoid giving too much or too little treatment. This is especially important in young patients or elderly individuals where side effects must be carefully managed. 

  • Monitoring Disease Through Blood (Liquid Biopsy) 
    One of the biggest breakthroughs? We can now track your response to treatment through blood. After starting therapy, if we see the cancer DNA disappear from your blood, it’s a strong sign you’re on the right path. 

  • Detecting Early Relapse or Resistance 
    Genomic liquid biopsy can even detect signs of relapse months before it shows up on scans or blood counts. That means earlier action, better outcomes. 

What’s New at Fortis Institute of Genomic Medicine? 

  • Lymphoma Genomic Testing: Get comprehensive results faster than ever before. 

  • ctDNA Liquid Biopsy for Lymphomas: No tissue, just a blood draw—and we can tell how your cancer is evolving in real time. 

  • Monitoring During Chemotherapy or CAR-T Cell Therapy: Track your recovery every step of the way with our advanced monitoring solutions. 

Who Should Consider Lymphoma Genomic Testing? 

  • Anyone newly diagnosed with lymphoma 

  • Patients starting or switching treatment 

  • Those being considered for CAR-T cell therapy 

  • People who want to monitor their disease without repeated biopsies 

Final Word: The Power Is in Your DNA 

Understanding your cancer at a genomic level means giving yourself the best shot at the right treatment, less toxicity, and better outcomes. And thanks to liquid biopsy, it’s now faster, safer, and less invasive than ever. 

At the Fortis Institute of Genomic Medicine, we believe precision medicine is not the future—it’s the present. 

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