Hand transplant is a treatment option for people who have had one or both hands amputated. In a hand transplant, you receive one or two donor hands and a portion of the forearms from a person who has died. Hand transplants are performed in only a few transplant centers worldwide.Although not guaranteed, a hand transplant may help you regain some hand function and sensation. While a hand transplant can improve your quality of life, it is a lifelong commitment to treatment. You'll need to take special medications (immunosuppressants) and have routine physical therapy and doctor appointments to check on the condition of your donor hands.